UTI Maintenance

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HOW TO DIAGNOSE A UTI

Until recently in Canada, UTI’s required a doctors diagnosis usually obtained via urine sample. Szio+ has made this process accurate and efficient by bringing the lab to you. Our test strips are developed with the same science and materials as those used in medical labs globally, providing you with accurate results within minutes.

Follow these easy steps to self-diagnose in the comfort of your own home:

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Hold test strip in urine stream for 1-2 seconds.

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Wait 1 minute to test Nitrite. Wait 2 for Leukocytes.

Do not read test results after 3 minutes.

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Compare results with colour chart:

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HOW TO TREAT A UTI

While the safest and most effective way to treat a UTI is with antibiotics prescribed by your doctor, research has shown that cranberries can also be an effective way of treating UTIs and their symptoms. Szio+ has worked with specialists to produce a cranberry concentration of 36PAC (Proanthocyanidin - the active component of cranberries) and has found, through clinical testing, that this dosage can effectively minimize the chances of bacteria (specially E. Coli) adhering to the urethra and bladder wall.

 
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Szio+ UTI Supplement (36mg PAC) are medical grade Canadian cranberry extract capsules made using Urophenol®, which is composed of PACs (Proanthocyanidins) - ingredients found deep within the juice concentrate of cranberries. Szio+ has created the Urinary Tract Health Supplement from locally grown cranberries in Canada.


WHAT IS UROPHENOL®?

Urophenol® is an ingredient which is obtained by extracting - with water and ethanol - the organic molecules contained in cranberries. These molecules are concentrated to obtain highly purified extracts of Proanthocyanidins (PACs). One of the only proven supplement concentrations that protects you from harmful bacteria that leads to painful UTIs.

Preventing UTIs with PACs

Proanthocyanidins - a powerful ingredient in Szio+ UTI Supplement (36mg PAC) - keeps your urinary tract in check. The PAC acts as a shield, blocking the bacteria from sticking to your bladder wall. Instead, the bacteria are naturally flushed away with your urine before they can do any harm. Taking just one Szio+ capsule a day can lead to results within hours.

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WANT THE SPECIFICS?

MOLECULES INVOLVED IN THE PREVENTION OF UTI

Cranberry polyphenols and in particular PAC are bioactive against UTI (Reed and Howell, 2009). Research has shown that cranberry PAC possesses a specific double interflavan bound, also known as A-type PAC, conferring anti-adhesion activity against uropathogenic Echerichia coli strains (Howell et al., 2005). PAC from other plant species have instead B-type single interflavan bounds and do not have this antiadhesion property (Howell et al., 2005). Foo et al. (Foo et al., 2000) have demonstrated that cranberry PAC trimers have more antiadhesion capacity than dimers or other oligomers. PAC with more than 3 flavan units are much less bioavailable than smaller ones (Deprez et al., 2001).


MODE OF ACTION OF PAC AGAINST UTI

PAC are polyphenol tannins that interact strongly with proteins and glycoproteins (Dangles and Dufour, 2006). They will prevent the adhesion of P-fimbriae, a proteinous extension at the surface of many gram-negative bacteria, by interacting with mannose receptors at the surface of the bladder epithelial cells (Ofek and Beachey, 1978). PAC have also been shown to prevent the formation of a biofilm, a protective community of multiplying bacteria enclosed in extrapolysaccharide substances at that surface of epithelial cells, which act as a defense barrier against antibiotic treatments (Pinzón-Arango et al., 2011).


ANTI-ADHESION PROPERTIES

PAC provide protection against uropathogenic bacteria by interacting with P-fimbriae in a dose dependant manner (Gupta et al., 2011; Tao et al., 2011). Liu et al. (Liu et al., 2006) showed that PAC caused an alteration of the conformation of fimbriae which make them less adhesive to surfaces. Extensive work by the group of Tufenkji also revealed that PAC reduced bacterial adhesion to surfaces (Eydelnan and Tufenkji, 2008; Tufenkji et al., 2010; O’May et al., 2012), while reducing bacterial motility ( Johnson et al., 2008; Hidalgo et al., 2011). They also block lectin-specific sites of the uropathogens thus preventing their adhesion to eukaryotic cells (Zafriri et al., 1989). The action of PAC is not only directed to the bacterial cells but also to the host cells. They are altering the cytoskeleton of the host epithelium cells, preventing the formation of pedestal structure beneath the adherent bacteria a process thought to be of critical importance for the establishment of a productive infection. PAC reduce E-coli induced inflammation of blood mononuclear cells and macrophage (Huang et al., 2009), a response most probably taking place also in the epithelial cells of the bladder {WANG:2000ga}. It has been suggested that PAC may tighten the junctions between cells (Lipson et al., 2011).

Clinical References for 36mg Proanthocyanidins

Does cranberry have a role in catheter-associated urinary tract infections?
~ Cranberry was effective in reducing the number of symptomatic CA-UTIs in all patients (n=22). Resistance to antibiotics was reduced by 28%. Furthermore, colony counts were reduced by 58.65%. 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698020/

 

Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study.
~ To prevent UTIs, inhibition of bacterial adhesion to epithelial cell lining is proven with 36 mg of PAC (proanthocyanidins Type A) a day.
~ For maximum efficacy to protect against bacterial adhesion, 72 mg of PAC (double-dose) may be taken for 2 days.
https://www.ncbi.nlm.nih.gov/pubmed/20398248

 

Cranberries for preventing urinary tract infections.
~ An updated Cochrane review of studies which determined that cranberry juice for the prevention of UTIs cannot be recommended.
~ It was identified that all studies did not utilize a standardized method of introduction (juice, capsule, pill) or to ensure the potency, and confirm they contained an adequate amount of the ‘active ingredient’ (36 mg PAC) for use in patients with recurrent UTIs.
https://www.ncbi.nlm.nih.gov/pubmed/23076891

SZIO+ UTI PRODUCTS

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