Szio+ Urinary Tract Health Supplement (36mg Proanthocyanidins)

Szio+ 36PAC UTI Prevention Supplement (Proanthocyanidin BL-DMAC)

$39.99CAD

Finally... a 36mg PAC Cranberry Supplement in Canada!

Each cranberry capsule contains 36mg Proanthocyanidins (PAC) - the active cranberry molecule
● Health Canada approved
● Multiple clinical trials in UTI prevention
● Made in Canada from 100% Natural Cranberries
● Antibiotic Free Prevention

Szio+ 36PAC UTI Prevention Supplements are a natural alternative to manage your recurrent Urinary Tract Infections (UTIs) with only 1 daily capsule. To reduce or eliminate the need for chronic antibiotic use, our formulation of 36mg PAC (Proanthocyanidin) is clinically proven to prevent recurrent UTIs at this specific concentration. Proanthocyanidins have been identified as the clinically effective component of cranberries which binds to E. Coli and prohibits them from adhering to the urinary tract wall.

Hospitals with Gynecologists, Urologists and Urogynes currently recommending include:

  • Sunnybrook Hospital

  • Mount Sinai Hospital

  • UHN (Toronto Western & Toronto General)

  • North York General

  • McKenzie Health Richmond Hill

  • Trillium Hospital

  • Credit Valley Hospital

  • St Boniface Hospital

  • Kingston General

  • St Pauls Hospital

  • And more...


RECOMMENDED DOSE - Recurrent UTI Prevention:
1 capsule daily at the same time

RECOMMENDED DOSE - Sex associated UTI Prevention:
2 capsules before/after sex
2 capsules the next day
OR 1 capsule daily if sexually active


MEDICINAL INGREDIENTS:
240 mg cranberry extract fruit powder (Vaccinium macrocarpon) providing 36 mg of proanthocyanidins (BL-DMAC)

NON MEDICINAL INGREDIENTS:
Pregelatinided starch, hypromellose, silicon dioxyde, magnesium sterate
Serving Size: 1 vegetal capsule.

NPN 80079601
30 vegicaps per box
 


A Personal Connection to UTIs…

Learn about our story to see where the passion for self-care and especially urinary tract infections originated from.

OUR STORY


About Szio+ 36PAC UTI Prevention Supplement

  • A clinically effective dose of 36mg PAC (Proanthocyanidin BL-DMAC method) in one daily capsule – the proven amount to prevent UTIs which works within hours.

  • Proanthocyanidins have been identified as active component of cranberries that creates a shield in your urinary tract to constantly protect it from UTI-causing bacteria

  • Additionally, proanthocyandins are known to provides high levels of antioxidants for the maintenance of good health

  • Szio+ 36mg PAC supplements are extracted from whole fresh cranberries which ensure we get different components than from pure cranberry juice. With whole fruit, you get the extractable components from the insoluble fibers part of the fruit (seeds, skins, pulp, flesh, etc) providing improved bioavailability and absorption.

  • Note that not all cranberry capsules and supplements are the same unless it states “36mg proanthocyanidins (BL-DMAC method)” within the medicinal ingredients.

  • Szio+ Urinary Tract Health Supplements (36mg proanthocyanidins) work on a 24-hour protection cycle and should be taken at the same time every day.

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Proanthocyanidins are clinically proven to be the active component from cranberries that prevent UTIs at a concentration of 36mg.

Cranberries have long been considered a natural treatment for Urinary Tract Infection symptoms and recurrences. At Szio+ we've identified the active molecule of the cranberry which is the Proanthocyanidins (PACs). Daily treatment at the right concentration (36mg PAC measured by the BL-DMAC Method) promotes natural flushing of the urinary tract by making the surface less adhesive to bacteria.


What healthcare professionals are saying...

"A natural way to take control of your UTI symptoms and effectively prevent and treat UTIs."

- Dr. Grace Liu
Obstetrics and Gynecologist
Sunnybrook Health Sciences Centre/Women’s College Hospital

"My mother has been using the urinary tract health supplement for a few months now and it has done wonders for her as she no longer feels discomfort when peeing and hasn’t had to use any antibiotics for a UTI in a while. She is extremely happy with her bladder function which makes me happy as well. Thank you for coming up with a great product"

- Registered Nurse Practitioner
Toronto, Ontario

Clinical References for Cranberry with 36mg Proanthocyanidins

Does cranberry have a role in catheter-associated urinary tract infections?

  • Cranberry was effective in reducing the number of symptomatic CA-UTIs in all patients (n=22). Resistance to antibiotics was reduced by 28%. Furthermore, colony counts were reduced by 58.65%. Source

Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study.

  • To prevent UTIs, inhibition of bacterial adhesion to epithelial cell lining is proven with 36 mg of PAC (proanthocyanidins Type A) a day.
  • For maximum efficacy to protect against bacterial adhesion, 72 mg of PAC (double-dose) may be taken for 2 days. Source

Cranberries for preventing urinary tract infections.

  • An updated Cochrane review of studies which determined that cranberry juice for the prevention of UTIs cannot be recommended.
  • It was identified that all studies did not utilize a standardized method of introduction (juice, capsule, pill) or to ensure the potency, and confirm they contained an adequate amount of the ‘active ingredient’ (36 mg PAC) for use in patients with recurrent UTIs. Source

Cranberry juice capsules and urinary tract infection post surgery: Results of a randomized trial.

  • The first randomized, double-blind, placebo-controlled trial of the therapeutic efficacy of cranberry juice capsules in preventing UTI post surgery.
  • Capsules contained 36mg Proanthocyanidin
  • The occurrence of UTI was significantly lower in the cranberry treatment group compared to the placebo group (15/80 (19%) versus 30/80 (38%).
  • Among women undergoing elective benign gynecologic surgery involving urinary catheterization, use of cranberry extract tablets during the postoperative period reduced the rate of UTI by half. Source

Pregnancy outcome after use of cranberry in pregnancy – the Norwegian mother and child cohort study

  • To investigate the safety of cranberry use during pregnancy, including any effects on congenital malformations and selected pregnancy outcomes.
  • Based on data from The Norwegian Mother and Child Cohort Study including more than 100,000 pregnancies from 1999 to 2008.
  • According to our data and the outcomes studied, cranberry does not appear to be a harmful adjunctive self-treatment.
  • Source

Szio+ 36PAC UTI Supplement Frequently Asked Questions

1. KEY POINTS OF THE SUPPLEMENT

  • 36mg Proanthocyanidins (PAC)
  • NPN: 80079601
  • Kosher/Halal/Made in Canada
  • 3 year shelf life
CLAIMS:
  • Used in herbal medicine to help prevent (recurrent) urinary tract infections
  • Provides antioxidants for the maintenance of good health

2. WHAT ARE PROANTHOCYANIDINS?

  • Proanthocyanidins (PACs) are clinically proven to be the active extract from cranberries and prevent UTIs at a concentration of 36mg.
  • It has been shown by many that cranberry polyphenols and in particular PAC are bioactive against UTI (Reed and Howell, 2009). Research has shown that cranberry PAC possesses a specific double interflavan bound, also known as A-type PAC, conferring anti-adhesion activity against uropathogenic Echerichia coli strains (Howell et al., 2005).

3. HOW DO PACS WORK?

  • PACs adhere to the bacteria and urinary tract to minimize and chance of adhering which promotes natural flushing.
  • Multiple studies have been conducted to show how PACs reduce bacterial adhesions to surfaces and cells along with reducing E-coli induced inflammation of blood mononuclear cells and macrophage.

4. WHAT MAKES OUR FORMULATION UNIQUE?

  • Urophenol® is the main ingredient which is obtained by extracting with water and ethanol, the organic molecules from whole cranberry fruits. These molecules are concentrated in a process to obtain highly purified extracts of Proanthocyanidins (PACs).
  • Most suppliers of any cranberry extract are using juice concentrate which do not provide the same polyphenol profile and bioavailability.
  • SZIO+ Urinary Health Tract Supplement utilizes the full 100% form of Urophenol®.

5. DIFFERENCE FROM D-MANNOSE

  • D-mannose is thought to block certain bacteria from growing in the urinary tract.
  • Product to take needs to consider the following: preventing or treating, dosage, format
  • Proanthocyanidins are still viewed as the active component in cranberries which requires a special process to provide the clinically effective dose of 36mg.

6. RECOMMENDED DOSAGE

  • Recurrent UTI Prevention - 36mg of PAC per day was the minimum amount to show significant benefit (1 capsule/day)
  • Sex associated UTI - 2 capsules before/after sex followed by 2 capsule the next day. 1 capsule/day for sexually active women
  • Provides a 24-hour protection cycle
  • Recommended to take at same time every day
  • Taken with water during mealtime

7. HOW IS A UTI TYPICALLY TREATED?

  • Urinary tract infection or UTI is a kind of infection that involves the organs of the urinary system like the bladder, kidneys, and urethra. Infection happens when bacteria enters the urinary system through the urethra and proliferates in the bladder.
  • Since a UTI is a bacterial infection, antibiotics are the usual UTI treatment given to patients. The type of antibiotic, however, still depends on the complexity of the infection and the general health of the patient.
  • A UTI test needs to be conducted first before any medication is prescribed to determine the kind of bacteria that causes the infection. Based from the results of the urinalysis, an appropriate antibiotic is prescribed to the patient.
  • If you are pregnant, allergic to antibiotics, more than 65 years old, or have suffered from side effects of antibiotics in the past, let your doctor know right away as these factors are important considerations in prescribing antibiotics.
  • Antibiotics are taken to kill the bacteria causing the infection. Minor cases of UTI are easily treated with antibiotics after a week or less while more serious cases may take a longer time. Listed below are some of the common antibiotics used to treat UTI.
  • Ampicillin
  • Fosfomycin
  • Cephalexin
  • Levofloxacin
  • Ciprofloxacin
  • Ceftriaxone
  • Nitrofurantoin
  • Patients with recurring UTI may be advised to undergo special treatments such as taking antibiotics in low dosage over an extended period, taking antibiotic after sexual intercourse (which is a common cause of infection), and using a urine-test kit whenever symptoms appear.
  • Severe cases of UTI such as those that have spread already in the kidneys may require hospitalization and high dosage of antibiotics administered through IV.
  • Your doctor may also prescribe pain killers like Tylenol and Ibuprofen to help alleviate the pain caused by infection. However, if you are against taking pain killers, using a heating pad may also help soothe the pain.
  • Consulting a doctor and heeding the doctor’s advice is crucial before undergoing UTI treatment. Prescription and dosage should be strictly followed. Doing otherwise may cause a minor UTI case to become a serious kidney infection.
  • After completing the prescription of your doctor, symptoms should improve within a few days. However, should the following things happen, contact your doctor right away:
  • Symptoms remain
  • Symptoms worsen
  • Symptoms came back after feeling well for some time
  • You experience bothersome side effects from your medication
  • It is important to always consult a doctor when UTI symptoms are experienced. However, there are still some remedies you can do at home to prevent the infection from recurring and speed up the recovery process.
  • Drinking plenty of water (6 to 8 glasses a day).
  • Reducing intake of fruit juice, soda, alcohol, sugar and processed foods.
  • Taking supplements to strengthen the immune system such as 36mg of Proanthocyanidin (PAC). PAC has been proven to reduce the ability of E. Coli bacteria to adhere on the bladder wall thus, providing protection from urinary tract infection. Aside from this, PAC also has antioxidant properties that helps reduce the risk of diabetes, heart disease and cardiovascular disease.

Want the Specifics on how Proanthocyanidins work?

1. MOLECULES INVOLVED IN THE PREVENTION OF UTI

Cranberry polyphenols and in particular PAC are bioactive against UTI (Reed and Howell, 2009). Research has shown that cranberry PAC possesses a specific double interflavan bound, also known as A-type PAC, conferring anti-adhesion activity against uropathogenic Echerichia coli strains (Howell et al., 2005). PAC from other plant species have instead B-type single interflavan bounds and do not have this antiadhesion property (Howell et al., 2005). Foo et al. (Foo et al., 2000) have demonstrated that cranberry PAC trimers have more antiadhesion capacity than dimers or other oligomers. PAC with more than 3 flavan units are much less bioavailable than smaller ones (Deprez et al., 2001).

2. MODE OF ACTION OF PAC AGAINST UTI

PAC are polyphenol tannins that interact strongly with proteins and glycoproteins (Dangles and Dufour, 2006). They will prevent the adhesion of P-fimbriae, a proteinous extension at the surface of many gram-negative bacteria, by interacting with mannose receptors at the surface of the bladder epithelial cells (Ofek and Beachey, 1978). PAC have also been shown to prevent the formation of a biofilm, a protective community of multiplying bacteria enclosed in extrapolysaccharide substances at that surface of epithelial cells, which act as a defense barrier against antibiotic treatments (Pinzón-Arango et al., 2011).

3. ANTI-ADHESION PROPERTIES

PAC provide protection against uropathogenic bacteria by interacting with P-fimbriae in a dose dependant manner (Gupta et al., 2011; Tao et al., 2011). Liu et al. (Liu et al., 2006) showed that PAC caused an alteration of the conformation of fimbriae which make them less adhesive to surfaces. Extensive work by the group of Tufenkji also revealed that PAC reduced bacterial adhesion to surfaces (Eydelnan and Tufenkji, 2008; Tufenkji et al., 2010; O’May et al., 2012), while reducing bacterial motility ( Johnson et al., 2008; Hidalgo et al., 2011). They also block lectin-specific sites of the uropathogens thus preventing their adhesion to eukaryotic cells (Zafriri et al., 1989). The action of PAC is not only directed to the bacterial cells but also to the host cells. They are altering the cytoskeleton of the host epithelium cells, preventing the formation of pedestal structure beneath the adherent bacteria a process thought to be of critical importance for the establishment of a productive infection. PAC reduce E-coli induced inflammation of blood mononuclear cells and macrophage (Huang et al., 2009), a response most probably taking place also in the epithelial cells of the bladder {WANG:2000ga}. It has been suggested that PAC may tighten the junctions between cells (Lipson et al., 2011).


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